2-(2-Amino-5-thiadiazolyl)-1-propyl-5-nitroimidazole → 2-(2-Amino-5-thiazolyl)-1-propyl-5-nitroimidazole

HRID 462241Notes

Reaction equation

HRID 462241 reaction equation
[CH2:1]([N:3]1C([N+]([O-])=O)=CN=C1C=CC1C=CC=CC=1)C.NN1[NH:24][CH:23]=[C:22]([C:25]2[N:26]([CH2:33][CH2:34][CH3:35])[C:27]([N+:30]([O-:32])=[O:31])=[CH:28][N:29]=2)[S:21]1>>[NH2:3][C:1]1[S:21][C:22]([C:25]2[N:26]([CH2:33][CH2:34][CH3:35])[C:27]([N+:30]([O-:32])=[O:31])=[CH:28][N:29]=2)=[CH:23][N:24]=1

Participants

3

Reactant 2

HCID 213908492-(2-Amino-5-thiadiazolyl)-1-propyl-5-nitroimidazoleHCID 54565136beta-(1-Ethyl-5-nitro-2-imidazolyl)styrene

Product 1

HCID 213908102-(2-Amino-5-thiazolyl)-1-propyl-5-nitroimidazole

Procedure

The procedure of Example 23, with the substitution of β-(1-propyl-5-nitro-2-imidazolyl)styrene for β-(1-ethyl-5-nitro-2-imidazolyl)styrene in the first step is utilized to prepare 2-(2-amino-5-thiadiazolyl)-1-propyl-5-nitroimidazole, melting at 234.5°-236° C.

Sources & evidence

ORD record
ord-ec7987e5ddcf489aa49674377b099cda
Source dataset
uspto-grants-1977_12
Patent number
US04065567

Reaction notes

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