反应详情

温度

40 °C

11 g (0.1 mol) of thiophenol and 18.9 g (0.11 mol) of 1-bromo-4-chlorobutane are mixed at ordinary temperature in a 250 ml flask equipped with a condenser, a thermometer and a dropping funnel. 100 ml of ethanol are added, the mixture is heated to 40° C and 20 ml of 5N NaOH are then added dropwise at this temperature. The speed of addition of the sodium hydroxide is regulated so as to have a reaction medium of neutral pH. When the addition is complete, the reactants are left in contact at 40° C for 3 hours, the alcohol is then evaporated, the oil is extracted with ether and the ether solution is washed with 2N NaOH and then with water. Thereafter the organic phase is dried over MgSO4, the ether is evaporated and a yellow oil ia obtained, which crystallises from ethanol. (18.4 g; 0.092 mol; yield: about 92%).

1. customequipped with a condenser
2. additionWhen the addition
3. customthe alcohol is then evaporated
4. extractionthe oil is extracted with ether
5. washthe ether solution is washed with 2N NaOH
6. dry with materialThereafter the organic phase is dried over MgSO4
7. customthe ether is evaporated
8. customa yellow oil ia obtained
9. customwhich crystallises from ethanol