反应详情

A mixture of 5-bromo-2-chloro-4-methoxybenzonitrile (30.7 g, 124 mmol) and NaOH (127 g, 3.11 mol) in EtOH (500 mL) and water (250 mL) was refluxed overnight. After cooling to room temperature, EtOH was removed under reduced pressure. The mixture was diluted with water and neutralized with hydrochloric acid (3.0 N). The resulting solid was filtered and dried in vacuo to give title compound (32.9 g, quantitative) as a white solid.

1. temperaturewas refluxed overnight
2. customEtOH was removed under reduced pressure
3. additionThe mixture was diluted with water and neutralized with hydrochloric acid (3.0 N)
4. filtrationThe resulting solid was filtered
5. customdried in vacuo