Triphenylphosphine Oxide → HCID 131710995, compound

Participants

Reaction Steps

To a solution of 0.5 millimole of tert-butyl 3-formyl-7-phenoxyacetamido-3-cephem-4-carboxylate-1-oxide in 10 cc. of dry benzene was added 175 mg. (1 equivalent) of (carbethoxymethylene)-triphenylphosphorane. After allowing the reaction mixture to stand at room temperature for 11 days, the solvent was removed under reduced pressure, the residue taken up in hot ethyl acetate, and cooled to yield 140 mg. of crystalline triphenylphosphine oxide (m.p., 155°-157° C.) as by-product.

Provenance & Evidence