Dichloromethane → HCID 70638720, compound

Participants

Reaction Steps

To a stirred, cooled (0°-5° C.) solution of 876 mg. of benzhydryl 7-acetamido-3-hydroxymethyl-3-cephem-4-carboxylate in a mixture of 40 ml. of methylene chloride and 20 ml. of isopropanol there was added dropwise 407 mg. (equivalent, about 85% pure) of m-chloroperbenzoic acid in 20 ml. of isopropanol, During the addition a precipitate was formed which was collected and washed with ethyl acetate yielding 800 mg. of the titled compound, m.p. 178°-179° C. The NMR, IR, and UV spectra were consistent with the assigned structure.

Provenance & Evidence