反应详情

温度

60 °C

To a solution of 10.8 g of sodium methylate in 50 ml of methanol are added 28.9 g of 2-amino-4-(3-chloropropyl)-6-trichloromethyl-1,3,5-triazine, and the mixture is stirred at 60° C. for 80 minutes. The formed suspension is filtered under suction, diluted with 250 ml of water, and extracted 3 times with 200 ml of ethylene chloride each time. The organic phases are dried, filtered, and concentrated by evaporation. The oil which remains is purified through a silica gel column, the eluant used being methylene chloride/ether (3:1). The eluant is evaporated off to leave 2.1 g of the title product, which is recrystallised from ether/chloroform, m.p. 158°-159° C.

1. filtrationThe formed suspension is filtered under suction
2. additiondiluted with 250 ml of water
3. extractionextracted 3 times with 200 ml of ethylene chloride each time
4. customThe organic phases are dried
5. filtrationfiltered
6. concentrationconcentrated by evaporation
7. customThe oil which remains is purified through a silica gel column
8. customThe eluant is evaporated off