HCID 13470486, compound → HCID 13470488, compound

Participants

Reaction Steps

5.2 g of 6-chlorohex-3-yn-1-ol t-butyldimethylsilyl ether in 50 ml of ethanol was hydrogenated under 1 atmosphere of hydrogen in the presence of 0.3 g of Lindlar catalyst wntil 370 ml of hydrogen had been absorbed. The catalyst was removed by filtration thru celite and the ethanol evaporated in vacuo. The crude product was chromatographed on 200 g of silica gel, eluting with 1 to 4% ether/hexane. Distillation of the appropriate fractions gave 3.7 g of 6-chlorohex-3Z-en-1-ol t-butyldimethylsilyl ether, bp 80°/0.5 mm.

Provenance & Evidence