反应详情

A mixture of 2.69 g. of 6-(p-bromophenyl)-3-chloropyridazine (U.S. Pat. No. 4,092,311), 3.12 g. of ethyl carbazate and 50 ml. of n-butanol is heated at reflux for 16 hours, then cooled and filtered giving an orange solid which is saved. The filtrate is heated at reflux for 23 hours, then chilled in an ice bath and filtered giving more orange solid. The two crops are combined and recrystallized from dimethylformamide, giving 0.65 g. of the desired product as orange crystals, m.p. 348°-350° C. (dec.).

1. additionA mixture of 2.69 g
2. temperatureat reflux for 16 hours
3. temperaturecooled
4. filtrationfiltered
5. customgiving an orange solid which
6. temperatureThe filtrate is heated
7. temperatureat reflux for 23 hours
8. temperaturechilled in an ice bath
9. filtrationfiltered
10. customgiving more orange solid
11. customrecrystallized from dimethylformamide
12. customgiving 0.65 g