HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazinecarboxylic acid, ethyl ester → 6-(p-Bromophenyl)-2-ethyl-7-methyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazinecarboxylic acid, ethyl ester | HCID 20064 | — |
| Reactant | 6-(p-bromophenyl)-7-methyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one | HCID 20398288 | — |
| Reactant | 3-(p-Bromophenyl)-6-chloro-4-methylpyridazine | HCID 20398289 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 6-(p-Bromophenyl)-2-ethyl-7-methyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one | HCID 13424601 | — |
Reaction Steps
A mixture comprising 328 g. of 3-(p-bromophenyl)-6-chloro-4-methylpyridazine (U.S. Pat. No. 4,092,311), 242 g. of ethyl carbazate and 2 liters of butanol is stirred at reflux for 4 days, then cooled in an ice bath. The resulting solid is collected by filtration and air dried, giving 269 g. of 6-(p-bromophenyl)-7-methyl-1,2,4-triazolo[4,3-b]pyridazin-3(2H)-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04515791 |
| Source dataset | uspto-grants-1985_05 |
| ORD ID | ord-d6682ab3a24e4b729f4473a4e4706efd |
| Source note | uspto-grants-1985_05 |