Hydrazinecarboxylic acid, ethyl ester → HCID 13424603, compound

HRID 462412Notes

Reaction equation

HRID 462412 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([F:16])[CH:9]=2)=[CH:6][CH:7]=1.[C:17](OCC)(=[O:20])[NH:18][NH2:19]>C(O)CCC>[F:16][C:10]1[CH:9]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]3[N:3]([C:17](=[O:20])[NH:18][N:19]=3)[N:4]=2)[CH:13]=[CH:12][C:11]=1[O:14][CH3:15]

Participants

4

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 203982843-Chloro-6-(3-fluoro-4-methoxyphenyl)pyridazine

Product 1

HCID 13424603HCID 13424603, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture comprising 4.0 g. of 3-chloro-6-(3-fluoro-4-methoxyphenyl)-pyridazine (U.S. Pat. No. 4,092,311), 3.54 g. of ethyl carbazate and 100 ml. of butanol is stirred at reflux for 3 days and then cooled in an ice bath. The resulting solid is collected by filtration and dried, giving 2.4 g. of the desired product as a tan solid, m.p. 289°-290° C.

Workup

  1. temperatureat reflux for 3 days
  2. temperaturecooled in an ice bath
  3. filtrationThe resulting solid is collected by filtration
  4. customdried
  5. customgiving 2.4 g

Sources & evidence

ORD record
ord-29a49613a3bc47d8bec0d2974de3a5f3
Source dataset
uspto-grants-1985_05
Patent number
US04515791

Reaction notes

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