反应详情

A mixture comprising 4.0 g. of 3-chloro-6-(3-fluoro-4-methoxyphenyl)-pyridazine (U.S. Pat. No. 4,092,311), 3.54 g. of ethyl carbazate and 100 ml. of butanol is stirred at reflux for 3 days and then cooled in an ice bath. The resulting solid is collected by filtration and dried, giving 2.4 g. of the desired product as a tan solid, m.p. 289°-290° C.

1. temperatureat reflux for 3 days
2. temperaturecooled in an ice bath
3. filtrationThe resulting solid is collected by filtration
4. customdried
5. customgiving 2.4 g