HCID 13457113, compound → HCID 13457123, compound

Participants

Reaction Steps

A solution of 2-[4-[3-chloro-4-(hydroxymethyl)phenyl]-1-piperazinyl]-1(3-nitrophenyl)ethanone (1.5 g, 3.8 m mole) in 100 ml of tetrahydrofuran was catalytically reduced at 25° over 0.5 g of Raney-Nickel with an average of three atmospheres of hydrogen. When the theoretical amount of hydrogen had been absorbed, the mixture was filtered and the filtrate was evaporated at reduced pressure to give a yellow solid which was recrystallized from acetonitrile to afford 0.95 g (69%), mp 174.5°-180° (Table 1). Prepared in the like manner were Cpd. 37 (Table 2) and 26 (Table 1).

Provenance & Evidence