Acetic Anhydride → HCID 70477487, compound

Participants

Reaction Steps

Methyl 2β-ethoxy-3α-hydroxy-11α-(3-methylbutylamino)-5α-androstane-17β-carboxylate (464 mg) in chloroform containing dry PTSA (344 mg) was stirred for 20 min, then treated with acetic anhydride (1.0 ml) and the mixture left for 3 h. The reaction mixture was diluted with ethanol and evaporated to give an oil. This was dissolved in ethyl acetate, washed with dilute ammonia solution (2×), water (1×), dried and evaporated to give an oil. This was purified by preparative t.l.c. in CHCl3 /MeOH (20:1) to give the title compound as an oil (415 mg), [α]D +27.9°, νmax 1725 cm-1.

Provenance & Evidence