Ethanol → HCID 70477852, compound

Participants

Reaction Steps

Methyl 11α-cyclohexylamino-3α-hydroxy-5α-androstane-17β-carboxylate (740 mg) in chloroform (8 ml) containing dry PTSA (640 mg) was stirred for 20 min then treated with acetic anhyride (1.9 ml) and left for 20 h. The reaction mixture was diluted with ethanol and evaporated to give an oil. This was dissolved in ethyl acetate, washed with dilute ammonia solution (2×) and water (1×), dried and evaporated to give a foam. This was purified by preparative t.l.c. in chloroform/methanol (9:1) to give a foam which was crystallised from acetonitrile to give the title compound, m.p. 87°-89° [α]D +16.9°.

Provenance & Evidence