Diethylamine → HCID 13079425, compound

Participants

Reaction Conditions

Reaction Steps

100 ml of dry benzene and 5.44 g of 1,3-diheptyl-2-ethyl isothiourea carbamyl chloride were placed in a 200 ml flask equipped with a thermometer and dropping funnel. A solution of 12 ml dry benzene and 2.19 g diethyl amine was added dropwise over 10-12 minutes. An exotherm raised the temperature from 21° to 30° C. The mixture was then heated to 45°-50° C. for 3 hours. The reaction mixture was then cooled to 15° C. and washed twice by 50 ml portions of cold water. The benzene phase was dried by MgSO4, filtered and the solvent removed under reduced pressure. 5.75 g of a liquid (96 weight percent of theory) having a nD30 of 1.4568 was recovered. The structure was confirmed as the title compound by mass spectra analyses. Compound No. 644 in Table I.

Provenance & Evidence