HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(Dimethoxymethyl)-4,6-dihydroxy-2,5,7,8-tetramethylchroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2-(Dimethoxymethyl)-6-hydroxy-2,5,7,8-tetramethyl-chroman-4-one | HCID 13051536 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(Dimethoxymethyl)-4,6-dihydroxy-2,5,7,8-tetramethylchroman | HCID 13051540 | 95% |
Reaction Steps
9.4 g (32 mmoles) of the product from Example 2 were reacted with 2.43 g (64 mmoles) NaBH4 in 100 ml of methanol at 20°-60° C. After 6 hours, a further 2.43 g of NaBH4 were added, after which the reaction mixture was stirred at room temperature for 16 hours. 100 ml of 3N NaOH were then added, and the mixture was neutralized with dilute hydrochloric acid and then extracted with ether, a brown oil being obtained as the crude product in 95% yield. IR: 3,600 (broad) cm-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04515975 |
| Source dataset | uspto-grants-1985_05 |
| ORD ID | ord-3b31a94508974d0fa5a521efc2916cd5 |
| Source note | uspto-grants-1985_05 |