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HRID46259

反应详情

EQUATION

反应方程式

HRID 46259 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(CN(c2nncs2)S(=O)(=O)c2cc(Cl)c(F)cc2F)c(OC)c1
HCID58042253

未命名化合物

结构：Nc1cc(-c2cc(Cl)ccc2O)ccn1
HCID136063619

未命名化合物

PRODUCTS

生成物

1
结构：Nc1cc(-c2cc(Cl)ccc2Oc2cc(F)c(S(=O)(=O)Nc3nncs3)cc2Cl)ccn1
HCID46841502

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 2-(2-aminopyridin-4-yl)-4-chlorophenol, (Preparation 721) and 5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide (Preparation 247) using a method analogous to that used in Preparation 669. Purification by semi-preparative HPLC using 15-100% MeOH/H2O yielded the title compound.

WORKUP

后处理

  1. customthat used in Preparation 669
  2. customPurification by semi-preparative HPLC