Water → HCID 20283993, compound

Participants

Reaction Steps

To a solution of 484 mg (2 mmol) of 3-methyl-2-(4-trifluoromethylphenylamino)butyronitrile in 5 ml of carbon tetrachloride was added 267 mg (2 mmol) of N-chlorosuccinimide. The mixture was heated at 65°. After about 48 hours, the mixture was poured into water and ether. The organic fraction was separated, washed with water and brine, dried over sodium sulfate, and solvent removed to give 3-methyl-2-(2-chloro-4-trifluoromethylphenylamino)butyronitrile in virtually quantitative yield.

Provenance & Evidence