Water → HCID 20283971, compound

HRID 462662Notes

Reaction equation

HRID 462662 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][CH:10]([CH:13]([CH3:15])[CH3:14])[C:11]#N)=[CH:5][CH:4]=1.[CH2:18]([OH:20])[CH3:19].Cl.[OH2:22]>>[F:1][C:2]([F:17])([F:16])[C:3]1[CH:8]=[CH:7][C:6]([NH:9][CH:10]([CH:13]([CH3:15])[CH3:14])[C:11]([O:20][CH2:18][CH3:19])=[O:22])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 962WaterHCID 134578853-Methyl-2-[4-(trifluoromethyl)anilino]butanenitrileHCID 21887872Ethanol hydrochloride

Product 1

HCID 20283971HCID 20283971, compound

Procedure

Following the procedure of Example 3, 2-(4-trifluoromethylphenylamino)-3-methylbutyronitrile was treated, at room temperature, with ethanol/HCl and then, at slightly lower temperature, with water to give ethyl 2-(4-trifluoromethylphenylamino)-3-methylbutanoate.

Sources & evidence

ORD record
ord-4016e1f575f7456ba7fa7bcc89e56538
Source dataset
uspto-grants-1985_05
Patent number
US04517130

Reaction notes

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