Ammonia → HCID 13365245, compound

Participants

Reaction Steps

Instead of the compound of formula (II) used in Example 1, ethyl 4-formyl-2,6-dimethyl-3-(o-trifluoromethylbenzoylamino)benzoate was used and reacted with ammonia in the same way as in Example 1. The reaction product was chromatographed on a silica gel column. The solvent was evaporated, and the residue was recrystallized from ethanol to give 2-(o-trifluoromethylphenyl)-7-ethoxycarbonyl-6,8-dimethylquinazoline having a melting point of 68° to 69° C. in a yield of 15%.

Provenance & Evidence