Phenylimidocarbonyl chloride → N-Phenyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

HRID 4627Notes

Reaction equation

HRID 4627 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=2)[O:11][CH2:12][CH2:13][CH2:14][NH:15][C:16]([NH:18][NH2:19])=[S:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30](Cl)Cl)=[CH:25][CH:24]=1>>[C:26]1([NH:29][C:30]2[S:17][C:16]([NH:15][CH2:14][CH2:13][CH2:12][O:11][C:10]3[CH:20]=[CH:21][CH:22]=[C:8]([CH2:7][N:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)[CH:9]=3)=[N:18][N:19]=2)[CH:27]=[CH:28][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 12145Phenylimidocarbonyl chlorideHCID 13402923N-(3-{3-[(Piperidin-1-yl)methyl]phenoxy}propyl)hydrazinecarbothioamide

Product 1

HCID 13657358N-Phenyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,3,4-thiadiazole-2,5-diamine

Procedure

The compound is prepared by a method analogous to that of Example 29 from N-[3-[3-(1-piperidinylmethyl) phenoxy]propyl]-hydrazine carbothioamide and phenyl isocyanide dichloride. The analytical values are summarized in Table II.

Sources & evidence

ORD record
ord-1dc6b5574bd346ad89e9cac4f2b34550
Source dataset
uspto-grants-1988_02
Patent number
US04727081

Reaction notes

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