2,6-Difluorobenzoyl isocyanate → HCID 20397098, compound

Participants

Reaction Steps

A solution of 2,6-difluorobenzoyl isocyanate (1.1 g) in dry toluene (5.0 ml) was added to a stirred solution of butyl 2-[[[4-(trifluoromethyl)phenyl]amino]thio]benzoate (1.9 g) in the same solvent (7.0 ml) at room temperature. After 18 hours, the reaction mixture was cooled to -5°, and the crystalline precipitate was separated, washing with cold toluene followed by light petroleum. The pure product was obtained as colourless crystals (2.5 g, melting point 79°-81°) after recrystallisation from diethyl ether/light petroleum.

Provenance & Evidence