Hydrochloric Acid → HCID 13457912, compound

Participants

Reaction Steps

To a stirred solution of cis-1,3,4,6,7,11b-hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinoline dihydrochloride (7.8 g, 0.023 m) and triethylamine (9.4 g, 0.093 m) in chloroform (100 ml) maintained at 0° under nitrogen was added dropwise hexanoyl chloride (4.79 g, 0.0356 m). The mixture was allowed to warm to ambient temperature and stirred for 3 hours, then treated with 10% HCl (25 ml). The layers were separated and the organic phase washed with 10% HCl (2×25 ml), water and dried over MgSO4. Evaporation of the solvent gave an oily residue which was dissolved in tetrahydrofuran and a white solid crystallized which was collected by filtration to give 6.4 g of cis-1,3,4,6,7,11b-hexahydro-2-hexanoyl-7-phenyl-2H-pyrazino[2,1-a]isoquinoline, m.p. 163°-164.5°. An additional 3.1 g of good purity product was recovered from the tetrahydrofuran to give a total of 9.5 g.

Provenance & Evidence