HCID 59436604, compound → HCID 178509253, compound

HRID 46274Notes

Reaction equation

[NH2:1][C:2]1[C:6]([C:7]2[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:8]=2[O:9][C:10]2[C:15]([Cl:16])=[CH:14][C:13]([S:17]([N:20](COC)[C:21]3[N:22]=[N:23][CH:24]=[CH:25][CH:26]=3)(=[O:19])=[O:18])=[C:12]([F:30])[CH:11]=2)=[CH:5][N:4](C2CCCCO2)[N:3]=1.NC1C(C2C=C(Cl)C=CC=2OC2C(Cl)=CC(S(/N=C3/N(COC)N=CC=C/3)(=O)=O)=C(F)C=2)=CN(C2CCCCO2)N=1>>[NH2:1][C:2]1[C:6]([C:7]2[CH:34]=[C:33]([Cl:35])[CH:32]=[CH:31][C:8]=2[O:9][C:10]2[C:15]([Cl:16])=[CH:14][C:13]([S:17]([NH:20][C:21]3[N:22]=[N:23][CH:24]=[CH:25][CH:26]=3)(=[O:19])=[O:18])=[C:12]([F:30])[CH:11]=2)=[CH:5][NH:4][N:3]=1

Participants

Reactant 2

HCID 59436604HCID 59436604, compound

HCID 59436629HCID 59436629, compound

Product 1

HCID 178509253HCID 178509253, compound

Procedure

The title compound was prepared according to the procedure in Example 1036 using 4-{2-[3-amino-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-4-chlorophenoxy}-5-chloro-2-fluoro-N-(methoxymethyl)-N-pyridazin-3-ylbenzenesulfonamide and 4-{2-[3-amino-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]-4-chlorophenoxy}-5-chloro-2-fluoro-N-[(3E)-2-(methoxymethyl)pyridazin-3(2H)-ylidene]benzenesulfonamide (Preparation 891).

Sources & evidence

ORD record: ord-05fafc8c381347678c3a956e20d327e5
Source dataset: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08541588B2

Reaction notes

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