反应详情

Alternatively, the present compound is prepared by reacting 5-chloro-6-hydroxynicotinic acid with I2 in an aqueous alkaline iodide solution to form 3-chloro-5-iodo-2-pyridinol. This reaction is conveniently conducted at an elevated temperature of between 40° C. and 150° C. and preferably at about 100° C. Lowering the pH of the reaction mixture to ≤1 such as, for example, by addition to the reaction mixture of SO2, will precipitate the 3-chloro-5-iodo-2-pyridinol from the reaction mixture.

1. customAlternatively, the present compound is prepared