Iodine → HCID 178517798, compound

HRID 462815Notes

Reaction equation

HRID 462815 reaction equation
[Cl:1][C:2]1[C:3]([OH:11])=[N:4][CH:5]=[C:6]([CH:10]=1)C(O)=O.[I:12]I.[I-]>>[Cl:1][C:2]1[C:3]([OH:11])=[N:4][CH:5]=[C:6]([I:12])[CH:10]=1

Participants

4

Reactant 3

HCID 807IodineHCID 30165Iodide IonHCID 178524771HCID 178524771, compound

Product 1

HCID 178517798HCID 178517798, compound

Procedure

Alternatively, the present compound is prepared by reacting 5-chloro-6-hydroxynicotinic acid with I2 in an aqueous alkaline iodide solution to form 3-chloro-5-iodo-2-pyridinol. This reaction is conveniently conducted at an elevated temperature of between 40° C. and 150° C. and preferably at about 100° C. Lowering the pH of the reaction mixture to ≤1 such as, for example, by addition to the reaction mixture of SO2, will precipitate the 3-chloro-5-iodo-2-pyridinol from the reaction mixture.

Workup

  1. customAlternatively, the present compound is prepared

Sources & evidence

ORD record
ord-de22360abd0e4778a4d43bb0df3d9b6c
Source dataset
uspto-grants-1985_05
Patent number
US04517368

Reaction notes

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