1,2,4-Trichlorobenzene → 1,3-Isobenzofurandione, 5-fluoro-

Participants

Reaction Steps

A mixture of 500 parts of 4,4-difluorohexahydrophthalic anhydride and 100 parts of 5 percent Pd/C catalyst in 3615 parts of 1,2,4-trichlorobenzene was charged to an autoclave reactor. The autoclave atmosphere was purged with nitrogen. The autoclave was then sealed, heated to about 250°-285° C. and maintained thereat for about 3.5 hours, then cooled to about room temperature. Analysis of the reaction product by gas chromatographic techniques, indicated a yield of about 51 percent 4-fluorophthalic anhydride, based on the difluorohexahydrophthalic anhydride reactant.

Provenance & Evidence