3-Amino-4-methoxy-1,2,5-thiadiazole 1-oxide → HCID 23312508, compound

HRID 462837Notes

Reaction equation

HRID 462837 reaction equation
CN(CC1N=C(OCCCN)C=CC=1)C.NC1C(OC)=NS(=O)N=1.[NH2:25][C:26]1[C:30]([NH:31][CH2:32][CH2:33][CH2:34][O:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][N:43]3[CH2:48]CCC[CH2:44]3)[N:37]=2)=[N:29][S:28](=O)[N:27]=1>>[NH2:25][C:26]1[C:30]([NH:31][CH2:32][CH2:33][CH2:34][O:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH2:42][N:43]([CH3:44])[CH3:48])[N:37]=2)=[N:29][S:28][N:27]=1

Participants

4

Reactant 3

HCID 159612163-Amino-4-methoxy-1,2,5-thiadiazole 1-oxideHCID 15961340HCID 15961340, compoundHCID 21292013HCID 21292013, compound

Product 1

HCID 23312508HCID 23312508, compound

Procedure

When a methanolic solution of 3-(6-dimethylaminomethyl-2-pyridyloxy)propylamine [prepared according to published U.K. patent application No. 2,098,988] is reacted with 3-amino-4-methoxy-1,2,5-thiadiazole 1-oxide according to the general procedure described in U.K. patent application No. 2,067,987 and the resulting 3-amino-4-[3-(6-piperidinomethyl-2-pyridyloxy)propylamino]-1,2,5-thiadiazole 1-oxide is successively reacted by the general procedure described in Example 1, Step A, and then by either Example 1, Step B, or Example 10, the title compound is thereby produced.

Sources & evidence

ORD record
ord-2cc4d840be4f4bdaba64860b2a667d2e
Source dataset
uspto-grants-1985_05
Patent number
US04517366

Reaction notes

Loading…