HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzaldehyde → Methyl 3-(4-chlorobenzoyl)pentanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzaldehyde | HCID 7726 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | Methyl 4-(4-chlorophenyl)-4-oxobutanoate | HCID 230774 | — |
| Reactant | Methyl pent-2-enoate | HCID 519179 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 3-(4-chlorobenzoyl)pentanoate | HCID 20281503 | 21% |
Reaction Steps
By the procedure described for the preparation of methyl 3-(4-chlorobenzoyl)propanoate (see Example 1), 4-chlorobenzaldehyde (22.48 g), methyl pent-2-enoate (13.65 g), and sodium cyanide (3.92 g) in dry dimethylformamide (DMF: 250 ml), followed by column chromatography on silica gel using dichloromethane: 40°-60° petrol (1:2) as eluent, gave methyl 3-(4-chlorobenzoyl)pentanoate (6.5 g, 21%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04518415 |
| Source dataset | uspto-grants-1985_05 |
| ORD ID | ord-058a3c3fcb4b4bbe89d9a3463b33cab7 |
| Source note | uspto-grants-1985_05 |