Hydrochloric Acid → 8-Amino-3-hydroxyoctanamide hydrochloride

Participants

Reaction Steps

To a solution of 1.04 g (3.2 mmoles) of 8-benzyloxycarbonylamino-3-hydroxyoctanamide in 20 ml of methanol were added 3.2 ml of 1N hydrochloric acid and 200 mg of 10% palladium-carbon. The mixture was stirred under a hydrogen stream at room temperature for 3 hours. The catalyst was removed by filtration and the filtrate was evaporated to dryness to yield 670 mg of 8-amino-3-hydroxyoctanamide hydrochloride.

Provenance & Evidence