Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | tert-Butylhydrazine monohydrochloride | HCID 81889 | — |
| Reactant | 4,4,4-trifluoro-1-(4-hydroxyphenyl)butane-1,3-dione | HCID 2771475 | — |
| Product | HCID 136063624 | HCID 136063624 | 63.3% |
Reaction Steps
A mixture of 4,4,4-trifluoro-1-(4-hydroxyphenyl)butane-1,3-dione (500 mg, 0.002 mol) and tert-butylhydrazine hydrochloride (270 mg, 0.0022 mol) in ethanol (12 mL, 0.21 mol) was heated at 150° C. in microwave for 1 h. Solvent was removed and the residue was purified via automated flash chromatography (silica gel, 0% to 30% ethyl acetate in hexanes) to give the product as an off-white solid (0.36 g, 60%). LCMS Rt=1.75 minutes
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08541588B2 |
|---|
| Source dataset | uspto-grants-2013_09 |
|---|
| ORD ID | ord-04c6a09b884548eab32332651a480000 |
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| Source note | uspto-grants-2013_09 |
|---|
