Piperazine → 8-(N-Benzyl-methylamino)-4-morpholino-2-piperazino-pyrimido-[5,4-d]-pyrimidine

HRID 462998노트

반응식

HRID 462998 반응식
[CH2:1]([N:8]([CH3:26])[C:9]1[C:14]2[N:15]=[C:16](Cl)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH2:1]([N:8]([CH3:26])[C:9]1[C:14]2[N:15]=[C:16]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 4837PiperazineHCID 128170202-chloro-8-(N-benzyl-N-methyl-amino)-4-morpholino-pyrimido[5,4-d]pyrimidine

생성물 1

HCID 128170748-(N-Benzyl-methylamino)-4-morpholino-2-piperazino-pyrimido-[5,4-d]-pyrimidine

실험 절차

This compound was prepared analogous to Example 118 from 8-(N-benzyl-methylamino)-2-chloro-4-morpholino-pyrimido-[5,4-d]-pyrimidine (m.p.: 121°-123° C.) and piperazine.

출처 및 근거

ORD 기록
ord-924007c4df4b4f9c95a099c3c61c7555
출처 데이터셋
uspto-grants-1985_05
특허 번호
US04518596

반응 노트

불러오는 중…