反应详情

To a stirred suspension of 4-chloro-2-iodophenol (305 mg, 1.20 mmol) and potassium carbonate (207 mg, 1.5 mmol) in dimethyl sulphoxide (5.0 ml) was added N-(5-chloro-1,3-thiazol-2-yl)-3-cyano-N-(2,4-dimethoxybenzyl)-4-fluorobenzenesulfonamide (Preparation 207, 468 mg, 1.00 mmol). Suspension stirred at room temperature for 18 hours. The reaction mixture was poured into ethyl acetate (20 ml) and saturated aqueous ammonium chloride solution (20 ml) and the aqueous layer extracted with ethyl acetate (3×20 ml). Combined organic layers were dried over magnesium sulfate and concentrated in vacuo. The crude residue was dissolved in dichloromethane (5 ml), trifluoroacetic acid (5 ml) was added and the reaction mixture was stirred at room temperature for 2 hours. The solvent was concentrated in vacuo and purified by ISCO™ preparative system eluting with dichloromethane:ethyl acetate (gradient 1:0 to 6:4, by volume) to afford the title compound as a solid, 396 mg, 72% yield.

1. extractionthe aqueous layer extracted with ethyl acetate (3×20 ml)
2. dry with materialCombined organic layers were dried over magnesium sulfate
3. concentrationconcentrated in vacuo
4. dissolutionThe crude residue was dissolved in dichloromethane (5 ml)
5. additiontrifluoroacetic acid (5 ml) was added
6. stirringthe reaction mixture was stirred at room temperature for 2 hours
7. concentrationThe solvent was concentrated in vacuo
8. custompurified by ISCO™ preparative system
9. washeluting with dichloromethane