Imidazole → HCID 20282802, compound

Participants

Reaction Steps

Bromomethyl-t-butyl ketone (17.9 g) (ref. J. Amer. Chem. Soc , 70, 2886 (1948)) was added to a solution of imidazole (34.1 g) in 34 ml of dimethylformamide. After stirring for 1 hour, 600 ml of water was added and the aqueous mixture extracted several times with ethyl acetate. The combined extracts were dried over sodium sulfate, concentrated, and the resulting oil chromatographed on silica gel, eluting with 5% methanol in methylene chloride, to give 3,3-dimethylbutan-2-on-1-yl imidazole.

Provenance & Evidence