Potassium Carbonate → HCID 20282280, compound

Participants

Reaction Steps

A solution of 1-[4-(4-chlorophenyl)-2-(4-acetylamino-2,6-dichlorophenoxy)-n-butyl]imidazole (1.58 g) (prepared as in Example 1) in 15 ml of concentrated hydrochloric acid was heated at 90° C. for 1 day. The resulting solution was poured into 200 ml of aqueous potassium carbonate solution, extracted with ethyl acetate (3×75 ml) and the combined extracts dried (MgSO4) and evaporated. The resulting oil (1.3 g) was dissolved in ether and treated with ethereal hydrogen chloride until precipitation was complete. The product was filtered off and dried immediately in vacuo to give 1.4 g of 1-[4-(4-chlorophenyl)-2-(4-amino-2,6-dichlorophenoxy)-n-butyl]imidazole bis(hydrochloride), m.p. 119°-123° C.

Provenance & Evidence