Methyl Isocyanate → HCID 20282703, compound

Participants

Reaction Steps

A solution of 1-[4-(4-chlorophenyl)-2-(4-aminophenylthio)-n-butyl]imidazole (360 mg) in dry tetrahydrofuran (10 ml) was treated with 0.16 ml of methyl isocyanate. The solution was warmed at gentle reflux overnight and the solvent evaporated. The residue was chromatographed on silica gel eluting with 2.2% water in ethyl acetate to give 1-[4-(4-chlorophenyl)-2-(4-methylaminocarbonylaminophenylthio)-n-butyl]imidazole.

Provenance & Evidence