反应详情

To 25 ml of surfuric acid was gradually added 8.5 g (0.049 mol) of 6-chloro-1,3-dimethyluracil as described in Synthesis Example 1. To the solution was gradually added at 0° to 5° C. 8.5 ml of fuming nitric acid and the mixture was stirred for 5 minutes. The reaction solution was poured onto ice and extracted twice with chloroform. The organic layer was dried with anhydrous magnesium sulfate, concentrated and the crystals thus-obtained were recrystallized from a solvent mixture of ethyl acetate and hexane to obtain 7.5 g of 6-chloro-1,3-dimethyl-5-nitrouracil.

1. customas described in Synthesis Example 1
2. additionTo the solution was gradually added at 0° to 5° C
3. additionThe reaction solution was poured onto ice
4. extractionextracted twice with chloroform
5. dry with materialThe organic layer was dried with anhydrous magnesium sulfate
6. concentrationconcentrated
7. customthe crystals thus-obtained
8. customwere recrystallized from a solvent mixture of ethyl acetate and hexane