Triethylamine → HCID 86740126, compound

Participants

Reaction Steps

Into 100 ml of chloroform were dissolved 10 g of 5-(2-aminoethyloxy)-1-benzylhydantoin and 4 g of triethylamine. While stirring, a solution of 11.9 g of α-bromo-α-(4-methoxybenzoyl)-2-chloro-5-dodecyloxycarbonylacetanilide in 50 ml of chloroform was added dropwise over a period of about 1 hour at room temperature. After being stirred for an additional 2 hours, the reaction mixture was condensed under reduced pressure, and the residue was purified by the use of a chromatographic column to give 14.1 g of α-(4-methoxybenzoyl)-α-[5-(2-aminoethyloxy)-1-benzyl-3-hydantoinyl]-2-chloro-5-dodecyloxycarbonylacetanilide. Yield. 92%. Oil.

Provenance & Evidence