Hydrochloric Acid → HCID 20283087, compound

Participants

Reaction Steps

A suspension of 12 g of 5% palladium on carbon, 135 g (0.369 mol) of 2-[3-(N-benzyl-N-methylamino)propyl]-2-(4-fluorophenyl)-1,3-dioxolane hydrochloride, 0.1 ml of a saturated solution of hydrogen chloride in methanol and 1 liter of methanol was shaken at 40° for 5 hours under 50 psi hydrogen. The suspension was allowed to cool to room temperature, filtered and the solvent evaporated. Trituration with anhydrous ether, followed by filtration provided 94.6 g (0.343 mol, 93%) of 2-(3-[methylamino]propyl)-2-(4-fluorophenyl)-1,3-dioxolane hydrochloride. Crystallization from isopropyl alcohol provided analytically pure material.

Provenance & Evidence