HCID 20283047, compound → HCID 20283051, compound

Participants

Reaction Steps

A suspension prepared from 47.2 g (0.124 mmol) of 2-[3-(N-benzyl-N-ethylamino)propyl]-2-(4-fluorophenyl)-1,3-dioxolane hydrochloride, 0.035 ml of saturated HCl/methanol, 350 ml of methanol, and 4 g of 5% palladium on carbon was shaken at 50° under 50 psi hydrogen for 5 hours. The mixture was allowed to cool to room temperature and filtered. Evaporation of the solvent followed by trituration with ether provided 34.8 g (96%) of product. Recrystallization from ether/isopropyl alcohol provided analytically pure material.

Provenance & Evidence