反应详情

To a solution of ethyl 2-hydroxyimino-3-oxobutyrate (syn isomer, 31.83 g) in chloroform (70 ml) was added dropwise sulfuryl chloride (29.7 g) over 6 minutes under ice-cooling, and the mixture was stirred for 4.5 hours at ambient temperature. The mixture was cooled to 7° C., and sulfuryl chloride (13.498 g) was further added thereto. The mixture was stirred at ambient temperature for overnight. After the reaction mixture was cooled with ice-water, chloroform (50 ml) and water (40 ml) were added thereto with stirring. The mixture was saturated with sodium chloride, and the organic layer was separated, washed with a saturated aqueous solution of sodium chloride (40 ml×2), dried over magnesium sulfate and then filtered. The filtrate was evaporated to give ethyl 2-hydroxyimino-3-oxo-4-chlorobutyrate (syn isomer), quantitatively.

1. temperaturecooling
2. temperatureThe mixture was cooled to 7° C.
3. stirringThe mixture was stirred at ambient temperature for overnight
4. additionwere added
5. stirringwith stirring
6. customthe organic layer was separated
7. washwashed with a saturated aqueous solution of sodium chloride (40 ml×2)
8. dry with materialdried over magnesium sulfate
9. filtrationfiltered
10. customThe filtrate was evaporated