Water → 5-Bromo-3-phenyl-2,1-benzisoxazole

HRID 463489Notes

Reaction equation

HRID 463489 reaction equation
[C:1]1([CH2:7][C:8]#N)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].[Br:12][C:13]1[CH:18]=C[C:16]([N+:19]([O-])=[O:20])=[CH:15][CH:14]=1.O>CO>[Br:12][C:13]1[CH:14]=[CH:15][C:16]2[C:8]([CH:18]=1)=[C:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[O:20][N:19]=2

Participants

6

Reactant 4

HCID 962WaterHCID 8794PhenylacetonitrileHCID 114661-Bromo-4-nitrobenzeneHCID 14797Potassium Hydroxide

Product 1

HCID 3472905-Bromo-3-phenyl-2,1-benzisoxazoleYield 55.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
50 °C

Procedure

Phenylacetonitrile (8.1 g, 69 mmol) was added to a room temperature solution of potassium hydroxide (85%) (74 g, 1.1 mol) in methanol (150 ml). To this was added 4-bromo-1-nitrobenzene (12.7 g, 63 mmol) suspended in methanol (130 ml). An exotherm was noted and the reaction was maintained at 50° C. for 5 hrs. After cooling to room temperature, water (400 ml) was added. The precipitate was collected and washed with water. The crude product (13.15 g) was crystallized from hot methanol (200 ml) to yield yellow needles (9.52 g, mp 113°-116° C.).

Workup

  1. temperatureAfter cooling to room temperature
  2. customThe precipitate was collected
  3. washwashed with water
  4. customThe crude product (13.15 g) was crystallized from hot methanol (200 ml)

Sources & evidence

ORD record
ord-3c282c395676426587958f3c34713f47
Source dataset
uspto-grants-1985_05
Patent number
US04519937

Reaction notes

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