反应详情

温度

200 °C

A 1-liter capacity flask equipped with N2 -bleeding tube, thermometer, paddle stirrer, and condenser was charged with 2-phenyl-4-quinolinecarboxylic acid, 227.7 g (0.90 mol), quinoline 200.0 g, and cupurons oxide 20.0 g (0.14 mol). The flask was heated with stirring to 200° C., and maintained at 200° C. for 1 hour. CO2 started to evolve at about 120° C. The mixture was cooled to room temperature, and filtered by suction using filter aid and ether. Ether was evaporated from the filtrate in a vacuum evaporator, and the residue was subjected to fractional distillation under vacuum. A fraction was collected at 140° C./0.2 mmHG-155° C./0.5 mmHg which was 99+% pure 2-phenylquinoline by GC, NMR. M.p. 80°-84° C. The yield was 82.0 g (44%).

1. customA 1-liter capacity flask equipped with N2 -bleeding tube
2. temperatureThe flask was heated
3. temperaturemaintained at 200° C. for 1 hour
4. customto evolve at about 120° C
5. temperatureThe mixture was cooled to room temperature
6. filtrationfiltered by suction
7. filtrationusing filter aid and ether
8. customEther was evaporated from the filtrate in a vacuum evaporator
9. distillationthe residue was subjected to fractional distillation under vacuum
10. customA fraction was collected at 140° C./0.2 mmHG-155° C./0.5 mmHg which