反应详情

A mixture of ethyl thiophene-2-carboxylate (12.0 g.) and ethylenediamine (15.4 ml.) was heated at 95°-100° C. for 48 hours. Excess ethylenediamine was removed under reduced pressure and the residue was dissolved in water (150 ml.). The insoluble material [bis(carboxamide)derivative] was removed by filtration. Evaporation of the filtrate gave a residue which was dissolved in toluene (50 ml.). The mixture was evaporated to give N-(2-aminoethyl)-thiophene-2-carboxamide as an oil (12.0 g.) essentially pure by TLC (Rf 0.90; SiO2 : 10% v/v methanol in chloroform as eluant) which was used without purification.

1. temperaturewas heated at 95°-100° C. for 48 hours
2. customExcess ethylenediamine was removed under reduced pressure
3. dissolutionthe residue was dissolved in water (150 ml.)
4. customThe insoluble material [bis(carboxamide)derivative] was removed by filtration
5. customEvaporation of the filtrate
6. customgave a residue which
7. customThe mixture was evaporated