Bromo(phenyl)acetic acid → HCID 13457847、化合物

HRID 463541ノート

反応式

HRID 463541 の反応式
[K].[SH:2][C:3]1[N:7]([CH3:8])[C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[N:4]=1.Br[CH:14]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:15]([OH:17])=[O:16]>CC(C)=O>[CH3:8][N:7]1[C:6]2[CH:9]=[CH:10][CH:11]=[CH:12][C:5]=2[N:4]=[C:3]1[S:2][CH:14]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:15]([OH:17])=[O:16]

参加物

5

反応物 3

HCID 97919Bromo(phenyl)acetic acidHCID 5462222PotassiumHCID 178481665HCID 178481665、化合物

生成物 1

HCID 13457847HCID 13457847、化合物収率 87%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

An acetone solution of 6.5 g (0.032M) of the potassium salt of 2-mercapto-1-methyl-benzimidazole and 9.7 g (0.045M) of α-bromophenylacetic acid is stirred at room temperature overnight. The solid which is collected is washed with water and the filtrate is concentrated to remove the solvent. The combined materials are recrystallized from acetonitrile. The recrystallized material weighs 8.3 g (87% yield) and melts at 157°-9° C.

後処理

  1. customThe solid which is collected
  2. washis washed with water
  3. concentrationthe filtrate is concentrated
  4. customto remove the solvent
  5. customThe combined materials are recrystallized from acetonitrile

出典と根拠

ORDレコード
ord-0e720e6359ac45a1ac14bdaecc5217cc
出典データセット
uspto-grants-1985_05
特許番号
US04520196

反応ノート

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