ethyl P-methyl-2-nitrophenylphosphinate → Ethyl (2-aminophenyl)(methyl)phosphinate

HRID 463552Notes

Reaction equation

HRID 463552 reaction equation
[CH3:1][P:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N+:13]([O-])=O)(=[O:6])[O:3][CH2:4][CH3:5]>C(O)C.[Pd]>[CH3:1][P:2]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[NH2:13])(=[O:6])[O:3][CH2:4][CH3:5]

Participants

4

Reactant 1

HCID 13292704ethyl P-methyl-2-nitrophenylphosphinate

Product 1

HCID 13292705Ethyl (2-aminophenyl)(methyl)phosphinate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl P-methyl-2-nitrophenylphosphinate (10 mmol) in ethanol (40 ml) containing 10% palladium on carbon (200 mg) is hydrogenated at atmospheric pressure. After cessation of hydrogen uptake, the mixture is filtered and evaporated to dryness to give ethyl P-methyl-2-aminophenylphosphinate.

Workup

  1. filtrationAfter cessation of hydrogen uptake, the mixture is filtered
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-366ef56cd49d4019bc7858dd2292b9cf
Source dataset
uspto-grants-1985_05
Patent number
US04520197

Reaction notes

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