Dichloromethane → (5E)-2,6-Dimethyl-5,7-octadien-2-ol

Participants

Reaction Steps

Into a 300-ml reactor equipped with a rectifying column (with an estimated number of theoretical plates of 10) filled with "Helipack" was charged 103 g (0.454 mol) of hydroxygeranyl diethylamine. The atmosphere was replaced with nitrogen. 33.6 ml (0.908 mmol) of the above-mentioned methylene chloride solution was added, and the reactants were heated under a reduced pressure of 1 mmHg. About 35 minutes after the reactant temperature in the flask had reached 150° C., distillation was started at a column top temperature of 63° C. After carrying out the reaction for 5 hours, a mixture of myrcenol and ocimenol was obtained in an amount of 59.4 g. The results from gas chromatography indicated that the mixture was composed of 87.6% of myrcenol and 12.4% of ocimenol.

Provenance & Evidence