Nitric Acid → 4-nitro-5-(2-chloro-4-trifluoromethylphenoxy)benzo-2,1,3-oxadiazole N-oxide

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Reaction Steps

5-(2-Chloro-4-trifluoromethylphenoxy)benzo-2,1,3-oxadiazole N-oxide (1.5 g, 4.5 mmol) is dissolved in 25 ml of ice-cold conc. sulfuric acid. To this is added dropwise 0.32 g (5.0 mmol) of nitric acid dissolved in 5 ml of conc. sulfuric acid. The mixture is allowed to stand for 30 minutes at 0°, and is then poured onto 100 g of ice. The solid is collected to give 4-nitro-5-(2-chloro-4-trifluoromethylphenoxy)benzo-2,1,3-oxadiazole N-oxide.

Provenance & Evidence