Ici 109,081 → HCID 13193369, compound

Participants

Reaction Steps

20.3 g (100 millimoles) of 6-(p-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone were stirred with 18.0 g (120 millimoles) of 2-acetoxypropionyl chloride and 400 ml of absolute acetone for 10 hours at room temperature. The product was filtered off under suction at 10° C., washed with cold acetone and dried at 70° C. under reduced pressure. 28.1 g (88.6%) of 6-[p-(2-acetoxypropionylamino)-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone were obtained. Mp.: 198°-200° C. (dimethylformamide/water).

Provenance & Evidence