Triethylamine → HCID 13193374, compound

Participants

Reaction Steps

20.3 g (0.1 mole) of 6-(p-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone were stirred with 18.1 g (0.12 mole) of 2-methoxybutyryl chloride and 10.1 g (0.1 mole) of triethylamine in 200 ml of absolute acetone for 3 hours at room temperature. 100 g of ice were added, the crystals were filtered off under suction and recrystallized from dimethylformamide/water, and the resulting product was dried at 50° C. under greatly reduced pressure. 18.9 g (63%) of 6-[p-(2-methoxybutyrylamino)-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone were obtained. Mp.: 151°-152° C.

Provenance & Evidence