Methyl malonyl chloride → HCID 13193388, compound

Participants

Reaction Steps

20.3 g (100 millimoles) of 6-(p-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone were stirred with 16.4 g (120 millimoles) of methyl chloroformylacetate and 400 ml of absolute acetone for 10 hours at room temperature. The product was filtered off under suction at 10° C., washed with cold acetone and dried at 70° C. under reduced pressure. 15.6 g (52%) of 6-[p-(methoxycarbonylacetylamino)-phenyl]-4,5-dihydro-5-methyl-3(2H)-pyridazinone were obtained. Mp.: 228°-230° C.

Provenance & Evidence