HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-(Methylsulfonamido)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Methylsulfonamido)benzoic acid | HCID 250653 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To 215.2 g (2.72 mole) of pyridine in 1250 ml of dichloromethane is added 238 g (1.44 mole) of ethyl 4-aminobenzoate. After cooling to 0° C., a solution of 177.6 g (1.55 mole) of methanesulfonyl chloride in 250 ml of dichloromethane is added with stirring. Upon completion of the addition, the ice bath is removed and the reaction is stirred for one hour at room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04544654 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-98f76ec3828f43fabcd0c535838e6578 |
| Source note | uspto-grants-1985_10 |